Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients

Abstract Iron-overload-associated cardiomyopathy has been one of the primary causes mortality in thalassemia patients with iron burden. There is growing evidence citing beneficial effects ebselen as an antioxidant selectively blocking divalent metal transporter 1 (DMT-1) to deter ingress into cardiomyocytes, raising internets viewing this component population order treat and even prevent occurring from surplus. In article, we reviewed potential advantageous who suffer excess, susceptible induced by overload. A systematic search several databases, including PubMed, Scopus, Web Science, was conducted explore role controlling iron-overload-related keywords Ebselen AND iron. The inclusion criteria were English-written preclinical clinical studies investigating efficacy side iron-overload context. After searching 44 articles found. Next, 19 published articles, 3 included article. reviewing references studies, no added. conclusion can be a promising adjuvant therapy alongside standard treatment chelators, particularly severe cases cardiomyopathy, due falling inflow inhibiting DMT-1 increasing ferroportin-1 expression properties. However, need carried out reach definite conclusion.